The goal of the WISP Study is to determine whether interval salpingectomy,
followed by delayed oophorectomy (ISDO) can
improve sexual functioning and menopausal
symptoms compared to standard risk-reducing
Women at increased risk of ovarian cancer based on
a genetic mutation are recommended to undergo
removal of the fallopian tubes and ovaries (RRSO) by
age 40 for BRCA1 and by age 45 for BRCA2.
For gene mutations including MLH1, MSH2, MSH6,
PMS2, BRIP1, RAD51C, and RAD51D, there are
recommendations to consider RRSO, although age is
The removal of both ovaries and the fallopian tubes
The removal of the fallopian tubes, while temporarily delaying the removal of the ovaries
The WISP Study is supported by the Stand Up To Cancer Ovarian Cancer-National Ovarian Cancer Coalition Dream Team.